Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study

Área de publicación Neurociencia Cognitiva
Tipo de publicación Articles
Lugar de publicación NeuroImage
Fecha de publicación 2021
Autores Graciela Muniz - Mak, E., Dounavi, M.E., Low, A., Carter, S.F., McKiernan, E., Williams, G.B., Jones, P.S., Carriere, I., Ritchie, K., Ritchie, C., Su, L., O'Brien, J.T.

Amongst cognitively normal midlife adults with a family history of dementia, a shorter hypothetical proximity to dementia onset may be associated with incipient brain abnormalities, characterised by white matter disruptions and perfusion abnormalities, particularly amongst APOE-ε4 carriers. Our findings also confer biological validity to the construct of EYO as a potential stage marker of preclinical progression in the context of sporadic dementia. Further clinical follow-up of our longitudinal sample would provide critical validation of these findings.

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