Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability

Área de publicación Neurociencia Cognitiva
Tipo de publicación Articles
Lugar de publicación Acta Neuropathologica Communications
Fecha de publicación 2021
Autores Claudia Duran-Aniotz - Moreno-Gonzalez, I., Gamez, N., Perez-Urrutia, N., Vegas-Gomez, L., Soto, C., & Morales, R.

Here, we tested the in vivo prion‐like transmission features of four AD brains displaying particular patterns of amyloidosis. AD brains induced different phenotypes in recipient mice, as evaluated by their specific seeding activity, as well as the total amount of Aβ deposited surrounding vascular structures and the reactivity of amyloid pathology to thioflavin S. Our results support the notion that AD‐subtypes are encoded in disease‐associated Aβ.

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