In this project we propose to study the role that immunity plays in the inverse relationship between AD and cancer. In recent years there has been important progress in the treatment of several cancers by unlocking immune tolerance with immune checkpoint inhibitors. There is also recent information suggesting that such a treatment is also beneficious in the 5xFAD model of AD by boosting inflammation and the entrance of myeloid cells to the brain which is accompanied by amyloid clearance and improvement in memory performance. We propose that a previous cancer leaves a systemic antitumoral immune response that induces a reduction of immune check point markers and therefore lower immune tolerance (proinflammatory state) that grants protection against the development of AD.
Co-I: Claudia Durán-Aniotz