This high-impact, interdisciplinary project seeks to identify biomarkers and early mechanistic pathways linking climate-related stressors to brain aging and neurodegeneration in vulnerable Latin American populations. It hypothesizes that chronic exposure to extreme heat progressively compromises blood-brain barrier (BBB) integrity—an early driver of neurodegeneration—further aggravated by air pollution, socioeconomic disadvantage, and comorbid health conditions.
PI: Agustin Ibañez, Josefina Cruzat & Agustina Legaz
Support:Wellcome Trust Discretionary Awards
