We will establish the sensitivity of multimodal EEG markers vis-à-vis cognitive (standardized coarse-grained cognitive tests), and neuroimaging ones (i.e., structural MRI, functional connectivity derived from fMRI) for discriminating among dementia subtypes (Ad vs FTD), status (familial vs sporadic) and predicting disease progression. We will implement a multi-feature analytical framework to characterize and predict the subtype, status, and clinical severity of neurodegenerative conditions via a novel multimodal electrophysiological markers (derived from EEG) neuroimaging pipeline (high density EEG, MRI and fMRI) and a set of sensitive behavioral (cognitive) measures.
PI: Agustin Ibanez
Support: Takeda Pharmaceuticals
